Heterobiaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part II

Biaryl purine derivatives such as 2 have demonstrated inhibition of cyclin dependent kinases and potent antiproliferative activity. Replacement of the C-6 biarylmethylamino group with heterobiarylmethylamino groups has afforded compounds such as 18g and 9c with significantly improved in vitro activity.