کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1374890 981927 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors
چکیده انگلیسی

A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.

ROCK inhibitors have been developed from 2-chromanyl- and 2-carboxamido-benzothiazoles. SAR studies and lead optimizations are described, which result in novel ROCK-II inhibitors with sub-nanomolar IC50s and good kinase selectivity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 23, 1 December 2009, Pages 6686–6690
نویسندگان
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