کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1374988 | 981929 | 2008 | 4 صفحه PDF | دانلود رایگان |
Acetogenins of the Annonaceae are strong inhibitors of mitochondrial complex I but discrepancies in the structure/activity relationships pled the search for other targets within the whole cell proteome. Combining hemisynthetic work, Cu-catalyzed Huisgen cycloaddition and proteomic techniques we have identified new putative protein targets of squamocin ruling out the previously accepted ‘complex I dogma’. These results give new insights into the mechanism of action of these potent neurotoxic molecules.
Combining hemisynthetic work, Cu-catalyzed Huisgen cycloaddition and proteomic techniques, we have identified new putative protein targets of squamocin ruling out the previously accepted ‘complex I dogma’ in the annonaceous acetogenin series.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 21, 1 November 2008, Pages 5741–5744