کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375001 | 981929 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of a novel decadentate ligand DEPA
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and biological evaluation of a novel decadentate ligand DEPA Synthesis and biological evaluation of a novel decadentate ligand DEPA](/preview/png/1375001.png)
چکیده انگلیسی
An efficient and short synthetic route to a novel decadentate ligand 7-[2-(bis-carboxymethyl-amino)-ethyl]-4,10-bis-carboxymethyl-1,4,7,10-tetraaza-cyclododec-1-yl-acetic acid (DEPA) with both macrocyclic and acyclic binding moieties is reported. A reproducible and scalable synthetic method to a precursor molecule of DEPA, 1,4,7-tris(tert-butoxycarbonylmethyl)tetraazacyclododecane was developed. DEPA was evaluated as a chelator of 177Lu, 212Bi, and 213Bi for potential use in an antibody-targeted cancer therapy, radioimmunotherapy (RIT) using Arsenazo III based spectroscopic complexation kinetics, in vitro serum stability, and in vivo biodistribution studies.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 21, 1 November 2008, Pages 5792–5795
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 21, 1 November 2008, Pages 5792–5795
نویسندگان
Hyun-Soon Chong, Sooyoun Lim, Kwamena E. Baidoo, Diane E. Milenic, Xiang Ma, Fang Jia, Hyun A. Song, Martin W. Brechbiel, Michael R. Lewis,