Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations

We have shown that manassantin A downregulated the HIF-1α expression and inhibited the secretion of VEGF. We have also demonstrated that the 2,3-cis-3,4-trans-4,5-cis-configuration of the tetrahydrofuran is critical to the HIF-1 inhibition of manassantin A.

HIF-1 inhibition by manassantin A (1) and analogues with modified tetrahydrofuran configurations (11 and 13) is reported.Figure optionsDownload as PowerPoint slide