کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375035 981931 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase
چکیده انگلیسی

We report the first synthesis of a 5S penem, known to bind bacterial type I signal peptidase, from the commercially available and inexpensive 6-aminopenicillanic acid. We report the first in vivo activity of the compound and use structure–activity relationship studies to begin to define the determinants of signal peptidase binding and also to begin to optimize the penem as an antibiotic.

The synthesis of a 5S penem inhibitor of bacterial signal peptidase is reported and shown to have activity against human pathogens and to be potentially optimizable for spectrum and activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 14, 15 July 2009, Pages 3787–3790
نویسندگان
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