Hypervalent iodine-catalyzed oxylactonization of ketocarboxylic acids to ketolactones

The hypervalent iodine-catalyzed oxylactonization of ketocarboxylic acids to ketolactones was achieved in the presence of iodobenzene (10 mol %), p-toluenesulfonic acid monohydrate (20 mol %) and meta-chloroperbenzoic acid as a stoichiometric co-oxidant.

The hypervalent iodine-catalyzed oxylactonization of ketocarboxylic acids to ketolactones was achieved in the presence of iodobenzene (10 mol %), TsOH (20 mol %) and m-CPBA as stoichiometric co-oxidant.Figure optionsDownload as PowerPoint slide