Efficient syntheses of chiral myo-inositol derivatives—key intermediates in glycosylphosphatidylinositol (GPI) syntheses

A facile and effective method was developed for large-scale syntheses of myo-inositol derivatives with the 1,2,6-O-positions differentiated from each other and from other positions as well. The syntheses started from methyl α-d-glucopyranoside, and the key steps are Ferrier rearrangement and a series of other regioselective and stereoselective reactions. The target compounds are key intermediates in the synthesis of GPIs.

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