Biomolecular assembly by iterative oxime ligations

Herein we describe an iterative oxime-based procedure to prepare multivalent bioconjugates. Our approach is illustrated by the assembly of structurally diverse tetravalent and a new generation of hexadecavalent glycoclusters.

We report an iterative oxime-based procedure for the assembly of biologically relevant carbohydrates and peptides onto a cyclopeptidic scaffold.Figure optionsDownload as PowerPoint slide