A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273

A novel ketone derivative of artemisinin, artemisitone-9, was produced by the biotransformation of cultured Streptomyces griseus ATCC 13273. The structure of the ketone product was fully elucidated by various spectroscopic techniques, and the mechanism of generating such novel metabolite is also discussed.

Artemisinin (1) was regioselectively converted to artemisitone-9 (2) and three other oxidative metabolites by Streptomyces griseus ATCC 13273.Figure optionsDownload as PowerPoint slide