کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375212 | 981933 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK1) antagonists
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK1) antagonists 1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK1) antagonists](/preview/png/1375212.png)
چکیده انگلیسی
1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK1 receptor antagonists. Substitution at the 6-exo-position led to high affinity NK1 antagonists with a prolonged duration of action in vivo. Incorporation of an α-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.
1-Phenyl-8-azabicyclo[3.2.1]octane ethers are NK1 receptor antagonists. Substitution at the 6-exo-position leads to high affinity NK1 antagonists with a prolonged duration of action in vivo. Incorporation of an α-methyl substituent in the pendent benzyl ether side chain gave compounds with increased selectivity over the hERG channel.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 7, 1 April 2006, Pages 2008–2012
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 7, 1 April 2006, Pages 2008–2012
نویسندگان
Ian T. Huscroft, Emma J. Carlson, Gary G. Chicchi, Marc M. Kurtz, Clare London, Piotr Raubo, Alan Wheeldon, Janusz J. Kulagowski,