کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375232 | 981934 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Probing with tool molecules, and by modeling and X-ray crystallography the binding modes of two structurally distinct series of DPP-4 inhibitors led to the discovery of a rare aromatic fluorine H-bond and the spatial requirement for better biaryl binding in the DPP-4 enzyme active site. These newly found binding elements were successfully incorporated into novel DPP-4 inhibitors.
The newly discovered aromatic fluorine H-bond and other binding elements in the DPP-4 inhibition were successfully incorporated into novel DPP-4 inhibitors such as 20a.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 13, 1 July 2008, Pages 3706–3710
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 13, 1 July 2008, Pages 3706–3710
نویسندگان
Gui-Bai Liang, Xiaoxia Qian, Tesfaye Biftu, Suresh Singh, Ying-Duo Gao, Giovanna Scapin, Sangita Patel, Barbara Leiting, Reshma Patel, Joseph Wu, Xiaoping Zhang, Nancy A. Thornberry, Ann E. Weber,