کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375240 981934 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline
چکیده انگلیسی

Two pyrrolizidinylalkyl derivatives of 4-amino-7-chloroquinoline (MG2 and MG3) were prepared and tested in vitro against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and in vivo in a Plasmodium berghei mouse model of infection. Both compounds exhibited excellent activity in all tests and low toxicity against mammalian cells. Preliminary studies of the acute toxicity and of the metabolism of the most active compound MG3 indicate a promising profile as a new antimalarial drug candidate.

New orally efficacious chloroquine analogs with excellent activity on CQ-R strains of P. falciparum.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 13, 1 July 2008, Pages 3737–3740
نویسندگان
, , , , , , , ,