کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375289 | 981936 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils Semi-synthetic analogs of pinitol as potential inhibitors of TNF-α cytokine expression in human neutrophils](/preview/png/1375289.png)
چکیده انگلیسی
Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-α expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-α cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.
Semi-synthetic analogs of pinitol were prepared using chemo-enzymatic approaches and their TNF-α expression in human neutrophils using flowcytometry is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 7, 1 April 2009, Pages 1939–1943
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 7, 1 April 2009, Pages 1939–1943
نویسندگان
Khurshid A. Bhat, Bhahwal A. Shah, Kuldeep K. Gupta, Anjali Pandey, Sarang Bani, Subhash C. Taneja,