Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators

An iterative analog library synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M1 positive allosteric modulators, and strategies for improving potency and plasma free fraction were identified.

A parallel synthesis approach was employed in the exploration of a quinolone carboxylic acid series of selective M1 positive allosteric modulators, identifying strategies for improving potency and plasma free fraction.Figure optionsDownload as PowerPoint slide