Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides

A series of hydrazonotrifluorosulfonanilide derivatives were synthesized and evaluated for in vitro activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. Some compounds with excellent activity against tick were identified.

A series of hydrazonotrifluoromethanesulfonanilide derivatives was prepared and assayed for activity against cat flea and brown dog tick. This led to discovery of potent acaricides 65 and 66.Figure optionsDownload as PowerPoint slide