Pyridine containing M1 positive allosteric modulators with reduced plasma protein binding

Incorporation of pyridines and diazines into the biphenyl region of quinolone carboxylic acid derived M1 positive allosteric modulators was investigated as a means of lowering plasma protein binding to enhance CNS exposure.

Incorporation of pyridines and diazines into the biphenyl region of quinolone carboxylic acid derived M1 positive allosteric modulators was investigated as a means of lowering plasma protein binding to enhance CNS exposure.Figure optionsDownload as PowerPoint slide