کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375415 | 981938 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Macrocyclic peptidyl hydroxamates were designed, synthesized, and evaluated as peptide deformylase (PDF) inhibitors. The most potent compound exhibited tight, slow-binding inhibition of Escherichia coli PDF (KI∗=4.4nM) and had potent antibacterial activity against Gram-positive bacterium Bacillus subtilis (MIC = 2–4 μg/mL).
Macrocyclic peptidyl hydroxamates were designed, synthesized, and evaluated as peptide deformylase (PDF) inhibitors. The most potent compound exhibited tight, slow-binding inhibition of Escherichia coli PDF (KI∗=4.4nM) and had potent antibacterial activity against Gram-positive bacterium Bacillus subtilis (MIC = 2–4 μg/mL).Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 10, 15 May 2008, Pages 3060–3063
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 10, 15 May 2008, Pages 3060–3063
نویسندگان
Gang Shen, Jinge Zhu, Anthony M. Simpson, Dehua Pei,