کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375453 981939 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficient synthesis of C-terminal modified peptide ketones for chemical ligations
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Efficient synthesis of C-terminal modified peptide ketones for chemical ligations
چکیده انگلیسی

Synthesis of a C-terminal modified peptide with an α-amido methylketone was efficiently carried out using a backbone-amide-type linker loading with a monofunctionalized diamine, provided that no base such as piperidine or diisopropylethylamine or a reducing agent such as triisopopylsilane was used for the synthetic pathway. The ketoxime-forming chemoselective ligation between a methylketone and an aminooxy was quantitative in 5 h at pH 2.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 24, 15 December 2005, Pages 5442–5445
نویسندگان
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