An approach to heterobifunctional poly(ethyleneglycol) bioconjugates

A family of differentially substituted poly(ethyleneglycol) building blocks has been assembled from commercially available material. Their utility is demonstrated by formation of amino acid conjugates, image contrast agents, gold nanoparticles, and functional antibody conjugates. Application in the cellular trafficking of antitumoral agent conjugates is expected.

A series of differentially substituted PEG building has been assembled from a readily available precursor. Application is demonstrated in the form of PEG derivatized biomolecules including labeled antibody conjugates.Figure optionsDownload as PowerPoint slide