کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375546 981941 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antioxidant and antiradical activities of resorcinarene tetranitroxides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Antioxidant and antiradical activities of resorcinarene tetranitroxides
چکیده انگلیسی

Resorcinarene oxazines bearing four TEMPO fragments at the wide rim of the macrocycle were prepared through the aminomethylation of resorcinarene octols with 4-amino-TEMPO and formaldehyde. Tetra-TEMPO resorcinarenes are efficient scavengers of 1,1-diphenyl-2-picrylhydrazyl radicals. The model studies revealed that macrocyclic structure and intramolecular hydrogen bonding make considerable contribution to antiradical activity of these compounds. Tetra-TEMPO resorcinarenes show also superoxide dismutase-like activity and efficiently inhibit ABAP-induced peroxidation of linoleic acid.

A resorcinarene oxazines bearing four TEMPO fragments at the wide rim exhibit a strong antiradical and antioxidant properties in model systems.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 5, 1 March 2009, Pages 1314–1317
نویسندگان
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