کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375555 | 981941 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators Identification of novel and potent 2-amino benzamide derivatives as allosteric glucokinase activators](/preview/png/1375555.png)
چکیده انگلیسی
The identification and structure–activity-relationships (SARs) of novel 2-amino benzamide glucokinase activators are described. Compounds in this series were developed to be potent GK activators, and their binding mode to the GK protein was determined by crystal structure analysis. In vivo pharmacokinetic and acute in vivo efficacy studies of compound 18 are also described.
The discovery and structure-activity-relationships of novel 2-amino benzamide glucokinase activators are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 5, 1 March 2009, Pages 1357–1360
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 5, 1 March 2009, Pages 1357–1360
نویسندگان
Teruyuki Nishimura, Tomoharu Iino, Morihiro Mitsuya, Makoto Bamba, Hitomi Watanabe, Daisuke Tsukahara, Kenji Kamata, Kaori Sasaki, Sumika Ohyama, Hideka Hosaka, Mayumi Futamura, Yasufumi Nagata, Jun-ichi Eiki,