Pseurotin A and its analogues as inhibitors of immunoglobuline E production

A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure–activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC50 of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found.

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