کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375580 | 981941 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FR290581, a novel sordarin derivative: Synthesis and antifungal activity
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: FR290581, a novel sordarin derivative: Synthesis and antifungal activity FR290581, a novel sordarin derivative: Synthesis and antifungal activity](/preview/png/1375580.png)
چکیده انگلیسی
Sordarin is a unique natural product antifungal agent that is an inhibitor of elongation factor 2. To improve biological activity, we synthesized various compounds by novel modification of the aglycone, sordaricin. As a result, we have discovered the novel sordarin derivative FR290581. This compound exhibited superior activity and a good pharmacokinetic profile, and also displayed good in vivo activity against Candida albicans.
We have discovered the novel sordarin derivative FR290581, which exhibited superior activity, a good pharmacokinetic profile and good in vivo activity.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 5, 1 March 2009, Pages 1465–1468
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 5, 1 March 2009, Pages 1465–1468
نویسندگان
Tadaatsu Hanadate, Masaki Tomishima, Nobuyuki Shiraishi, Daisuke Tanabe, Hiroshi Morikawa, David Barrett, Satoru Matsumoto, Kazumi Ohtomo, Katsuyuki Maki,