کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375582 981941 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Construction of arginine-rich peptide displaying bionanocapsules
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Construction of arginine-rich peptide displaying bionanocapsules
چکیده انگلیسی

Bionanocapsule (BNC) is a hollow nanoparticle composed of L-protein of the hepatitis B virus surface antigen. BNC can deliver genes or drugs into specific human hepatocytes, but delivery is limited to hepatocytes. In this study, we attempted to alter the specificity of BNCs by genetically introducing cell-penetrating peptides (CPPs), such as arginine-rich peptides, into BNCs. The CPP-fused BNC was efficiently internalized into various cell lines in a short period without significant cytotoxicity. These results show that CPP-BNC could be applied as an efficient carrier for gene and drug delivery.

Bionanocapsules displaying cell-penetrating peptide (CPP-BNC) was constructed. CPP-BNC was efficiently internalized into various cell lines in a short time, compared with original BNC.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 5, 1 March 2009, Pages 1473–1476
نویسندگان
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