کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375632 981942 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Curcumin is a potent DNA hypomethylation agent
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Curcumin is a potent DNA hypomethylation agent
چکیده انگلیسی

Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with an IC50 of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 μM. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line.

A potent dietary DNA methylation inhibitor, curcumin 1 (EC50 = 30 nM) and its hypomethylation activity on MV4-11 cells (15–20% decrease in global DNA methylation) is reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 3, 1 February 2009, Pages 706–709
نویسندگان
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