کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375661 981942 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of a Streptococcus pyogenes vaccine candidate based on the M protein PL1 epitope
چکیده انگلیسی

Group A streptococcus is a Gram-positive bacteria that causes a range of infectious diseases. Targeting the bacteria, a new self-adjuvanting vaccine candidate, incorporating a carbohydrate carrier and an amino acid-based adjuvant, was synthesised utilising carbohydrate chemistry and solid-phase peptide synthesis procedures. Characterisation of the candidate was achieved using reverse-phase HPLC and electrospray ionisation mass spectrometry. The successful synthesis and characterisation of the vaccine candidate may contribute to the discovery of a therapeutically and clinically viable vaccine against group A streptococcus.

A complex vaccine candidate against group A streptococcus incorporating carrier, adjuvant and the antigen was synthesised using carbohydrate chemistry and solid-phase peptide methods.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 3, 1 February 2009, Pages 821–824
نویسندگان
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