Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues

A series of thieno[3,2-b]pyrroloazepinones derivatives related to Hymenialdisine were prepared and tested for CHK1 inhibitory activity. Nanomolar inhibitions were achieved when electron-withdrawing substituents were introduced at position 3 of the thiophene ring.

Thieno[3,2-b]pyrroloazepinones analogues of Hymenialdisine were prepared and found to be potent inhibitors of CHK1.Figure optionsDownload as PowerPoint slide