Pharmacophore-based design, synthesis, biological evaluation, and 3D-QSAR studies of aryl-piperazines as α1-adrenoceptor antagonists

In the present paper, we successfully designed a series of potent aryl-piperazines as α1-AR antagonists based on a three-point pharmacophore. The 3D-QSAR study of this series of aryl-piperazines may provide some useful information for the designing of more potent aryl-piperazine analogues as α1-adrenoceptor antagonists.