کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375719 | 981943 | 2005 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Sialyl Lewisx analogs based on a quinic acid scaffold as the fucose mimic Sialyl Lewisx analogs based on a quinic acid scaffold as the fucose mimic](/preview/png/1375719.png)
(−)-Quinic acid was used as a starting material for the preparation of sialyl Lewisx mimetics in order to target E-selectin. Spatial orientation of the hydroxyl groups of quinic acid could mimic the l-fucose ones. Introduction of a side chain ending with a carboxylic acid was effected to replace the sialic acid interaction at the carbohydrate recognition domain. A first series of derivatives, incorporating amino acids linked to quinic acid, were tested for their affinity and found to interact with E-selectin with IC50 within the millimolar range.
(−)-Quinic acid was used as a starting material for the preparation of sialyl Lewisx mimetics to target E-selectin. Spatial orientation of the hydroxyl groups of quinic acid could mimic the l-fucose ones. Introduction of a side chain ending with a carboxylic acid was effected to replace the sialic acid interaction at the carbohydrate recognition domain. A first series of derivatives, incorporating amino acids linked to quinic acid, were tested for their affinity and found to interact with E-selectin with IC50 within the millimolar range.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 13, 1 July 2005, Pages 3224–3228