Binding studies of cationic uridyl ribonucleic guanidine (RNG) to DNA

Replacement of the phosphodiester linkages of the polyanionic uridyl RNA with guanidium linkers provides polycationic uridyl ribonucleic guanidine (RNG) as a putative antisense/antigene agent. DNA binding characteristics of cationic uridyl RNG are described.