کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375768 | 981944 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing 4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing](/preview/png/1375768.png)
چکیده انگلیسی
The synthesis and ΔF508-CFTR corrector activity of a 148-member methylbithiazole-based library are reported. Synthetic routes were devised and optimized to generate methylbithiazole analogs in four steps. Corrector potency and efficacy were assayed using epithelial cells expressing human ΔF508-CFTR. These structure–activity data establish that the bithiazole substructure plays a critical function; eight novel methylbithiazole correctors were identified with low micromolar potencies.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 8, 15 April 2008, Pages 2610–2614
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 8, 15 April 2008, Pages 2610–2614
نویسندگان
Choong Leol Yoo, Gui Jun Yu, Baoxue Yang, Lori I. Robins, A.S. Verkman, Mark J. Kurth,