کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1375783 | 981944 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We describe the medicinal chemistry approach that generated a novel indole series of EP1 receptor antagonists. The SAR of this new template was evaluated and culminated in the identification of compound 12g which demonstrated in vivo efficacy in a preclinical model of inflammatory pain.
The discovery, synthesis, and biological activity of a novel series of indole EP1 receptor antagonists is described, such as compounds 10a and 12g. Compound 12g demonstrated in vivo efficacy in a preclinical model of inflammatory pain.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 8, 15 April 2008, Pages 2684–2690
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 8, 15 April 2008, Pages 2684–2690
نویسندگان
Adrian Hall, Andy Billinton, Susan H. Brown, Anita Chowdhury, Gerard M.P. Giblin, Paul Goldsmith, David N. Hurst, Alan Naylor, Sadhana Patel, Tiziana Scoccitti, Pamela J. Theobald,