کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375783 981944 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping
چکیده انگلیسی

We describe the medicinal chemistry approach that generated a novel indole series of EP1 receptor antagonists. The SAR of this new template was evaluated and culminated in the identification of compound 12g which demonstrated in vivo efficacy in a preclinical model of inflammatory pain.

The discovery, synthesis, and biological activity of a novel series of indole EP1 receptor antagonists is described, such as compounds 10a and 12g. Compound 12g demonstrated in vivo efficacy in a preclinical model of inflammatory pain.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 8, 15 April 2008, Pages 2684–2690
نویسندگان
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