کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375840 981946 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure–activity relationships
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure–activity relationships
چکیده انگلیسی

The synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6-(tert-butyl)thieno[2,3-d]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure–activity relationship of this series of compounds are discussed.

New analogues of thieno[2,3-d]pyrimidin-4-yl hydrazone compounds as Cyclin D1/CDK4 inhibitors have been synthesized and evaluated their enzyme inhibitory activity and antiproliferative activity. The potency, selectivity profile, and structure–activity relationship trends of this class of compounds are discussed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 2, 15 January 2009, Pages 305–308
نویسندگان
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