کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1375880 981946 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity
چکیده انگلیسی

A dual activity, conjugated approach has been taken to form hybrid molecules of two known antimalarial drugs, chloroquine (CQ) and the non-sedating H1 antagonist astemizole. A variety of linkers were investigated to conjugate the two agents into one molecule. Compounds 5–8 possessed improved in vitro activity against a CQ-resistant strain of Plasmodium falciparum, and examples 7 and 8 were active in vivo in mouse models of malaria.

A series of novel hybrids of CQ and astemizole have been shown to possess potent in vitro and in vivo antiplasmodial activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 2, 15 January 2009, Pages 481–484
نویسندگان
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