11-Phenyl-[b,e]-dibenzazepine compounds: Novel antitumor agents

A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC50 values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G0–G1 phase transition resulting in G0–G1 arrest.

A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC50 values ranging from submicromolar to micromolar concentrations.Figure optionsDownload as PowerPoint slide