Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (−)-kaitocephalin

The design and synthesis of four pyrrolidine scaffolds that are structurally related to the known ionotropic glutamate receptor antagonist, (−)-kaitocephalin, is described. Additionally, preliminary results of the biological evaluation of these compounds are disclosed.

The design, synthesis, and biological activity of a series of aryl substituted 2,2,5-disubstituted pyrrolidines that are structurally related to the known ionotropic glutamate receptor antagonist, (−)-kaitocephalin, is described.Figure optionsDownload as PowerPoint slide