کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376065 | 981949 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells Novel potent organoselenium compounds as cytotoxic agents in prostate cancer cells](/preview/png/1376065.png)
A series of 17 symmetrical substituted imidothiocarbamate and imidoselenocarbamate derivatives has been synthesized by reacting appropriately substituted acyl chlorides with alkyl imidothiocarbamates and alkyl imidoselenocarbamates. The antitumoral activities of the compounds were evaluated in vitro by examining their cytotoxic effects against human prostate cancer cells (PC-3). Five compounds showed interesting activity levels and 3p (IC50 = 1.85 μM) was 7.3 times more active than the standard etoposide used in the treatment of prostate cancer and emerges as the most interesting compound.
Significant in vitro antiproliferative activity against human prostate cancer cell (PC-3) of novel symmetrical imidoselenocarbamates is showed.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 24, 15 December 2007, Pages 6853–6859