Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library

A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. High-throughput screening of this library for anti-tuberculosis activity identified several members with a MIC90 value of 12.5 μg/mL.

Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library 1 as Mureidomycin mimetics are described.Figure optionsDownload as PowerPoint slide