Synthesis and biological evaluation of C-12′ substituted vinflunine derivatives

A series of novel C-12′ substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.

A series of novel C-12′ substituted vinflunine derivatives have been synthesized. Several compounds in this series possess comparable in vitro cytotoxic potency against A549 cell lines.Figure optionsDownload as PowerPoint slide