کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376180 981951 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable
چکیده انگلیسی

Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability.

The discovery and SAR of a novel class of imidazole-alkene-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro and in cells is reported. These compounds are lead-like with low molecular weight and good physical properties, and are orally bioavailable.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 16, 15 August 2008, Pages 4723–4726
نویسندگان
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