کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376180 | 981951 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Tie-2 is a receptor tyrosine kinase which is involved in angiogenesis and thereby growth of human tumours. The discovery and SAR of a novel class of imidazole-vinyl-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro is reported. Their synthesis was carried out by condensation of imidazole aldehydes with methyl pyrimidines. These compounds are lead-like, with low molecular weight, good physical properties and oral bioavailability.
The discovery and SAR of a novel class of imidazole-alkene-pyrimidine kinase inhibitors, which inhibit Tie-2 in vitro and in cells is reported. These compounds are lead-like with low molecular weight and good physical properties, and are orally bioavailable.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 16, 15 August 2008, Pages 4723–4726
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 16, 15 August 2008, Pages 4723–4726
نویسندگان
David Buttar, Mike Edge, Steve C. Emery, Martina Fitzek, Cheryl Forder, Alison Griffen, Barry Hayter, Chris F. Hayward, Philip J. Hopcroft, Richard W.A. Luke, Ken Page, John Stawpert, Andy Wright,