کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376233 981952 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bradykinin B1 receptor antagonists: An α-hydroxy amide with an improved metabolism profile
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Bradykinin B1 receptor antagonists: An α-hydroxy amide with an improved metabolism profile
چکیده انگلیسی

A series of carbo- and heterocyclic α-hydroxy amide-derived bradykinin B1 antagonists was prepared and evaluated. A 4,4-difluorocyclohexyl α-hydroxy amide was incorporated along with a 2-methyl tetrazole in lieu of an oxadiazole to afford a suitable compound with good pharmacokinetic properties, CNS penetration, and clearance by multiple metabolic pathways.

The design and synthesis of human bradykinin B1 antagonists featuring N-methyl tetrazole and α-hydroxy amide moieties are disclosed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 18, 15 September 2008, Pages 5107–5110
نویسندگان
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