کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376261 981954 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure–activity study
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure–activity study
چکیده انگلیسی

The antimalarial activity of hyperforin, a phenol-like compound that can be easily absorbed orally, and a series of derivatives variously modified on the cyclohexatrienone system was investigated. Hyperforin was active against Plasmodium falciparum with an IC50 value in the micromolar range, and the activity was not critically dependent on either its phenol-like sensitivity to autooxidation or the presence of unsaturation on the prenyl residues. Related phloroglucinols like the hop β-acids and the enantiomers of usnic acid showed only marginal activity, suggesting that hyperforin is a new antimalarial chemotype.

The antimalarial activity of hyperforin and a series of derivatives variously modified on the cyclohexatrienone system was investigated. Hyperforin was active against Plasmodium falciparum with an IC50 value in the micromolar range, and the activity was not critically dependent on either its phenol-like sensitivity to autooxidation or the presence of unsaturation on the prenyl residues.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 6, 15 March 2007, Pages 1544–1548
نویسندگان
, , , ,