کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376264 | 981954 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor](/preview/png/1376264.png)
To identify prodrugs of a thiolate histone deacetylase inhibitor NCH-31 that show potent antiproliferative activity and are stable in human plasma, we synthesized several candidate prodrugs of NCH-31. Among these compounds, S-2-methyl-3-phenylpropanoyl compound 2 showed more potent antiproliferative activity and higher stability in human plasma than S-isobutyryl compound NCH-51.
To identify prodrugs of a thiolate histone deacetylase inhibitor NCH-31 that show potent antiproliferative activity and are stable in human plasma, we synthesized several S-acyl derivatives of NCH-31. Among these compounds, S-2-methyl-3-phenylpropanoyl compound 2 showed potent antiproliferative activity and high stability in human plasma.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 6, 15 March 2007, Pages 1558–1561