کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376299 | 981954 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxazolidinones as novel human CCR8 antagonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a), are described.
High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series that led to the identification of SB-649701 (1a) are described.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 6, 15 March 2007, Pages 1722–1725
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 6, 15 March 2007, Pages 1722–1725
نویسندگان
Jian Jin, Yonghui Wang, Feng Wang, Jeffery K. Kerns, Victoria M. Vinader, Ashley P. Hancock, Matthew J. Lindon, Graeme I. Stevenson, Dwight M. Morrow, Parvathi Rao, Cuc Nguyen, Victoria J. Barrett, Chris Browning, Guido Hartmann, David P. Andrew,