کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376342 | 981956 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis, and structure–activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARα/γ agonists
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Design, synthesis, and structure–activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARα/γ agonists Design, synthesis, and structure–activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARα/γ agonists](/preview/png/1376342.png)
چکیده انگلیسی
Several series of substituted dehydropiperidine and piperidine-4-carboxylic acid analogs have been designed and synthesized as novel, potent dual PPARα/γ agonists. The SAR of these series of analogs is discussed. A rare double bond migration occurred during the basic hydrolysis of the α,β-unsaturated dehydropiperidine esters 12, and the structures of the migration products were confirmed through a series of 2D NMR experiments.
The SAR of substituted dehydropiperidine and piperidine-4-carboxylic acid analogs as novel, potent dual PPARα/γ agonists is discussed. A rare double bond migration in dehydropiperidine series has been observed and discussed.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 12, 15 June 2008, Pages 3545–3550
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 12, 15 June 2008, Pages 3545–3550
نویسندگان
Xiang-Yang Ye, Yi-Xin Li, Dennis Farrelly, Neil Flynn, Liqun Gu, Kenneth T. Locke, Jonathan Lippy, Kevin O’Malley, Celeste Twamley, Litao Zhang, Denis E. Ryono, Robert Zahler, Narayanan Hariharan, Peter T.W. Cheng,