کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376346 981956 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
چکیده انگلیسی

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.

Novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of enoyl-ACP reductase from Bacillus anthracis.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 12, 15 June 2008, Pages 3565–3569
نویسندگان
, , , , , , , ,