کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376378 | 981957 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and optimization of potent, selective antagonists of Oxytocin
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
A novel series of Oxytocin antagonists are described. This series was identified through pharmacophoric overlap of in-house and literature antagonists. Subsequent optimization led to a series of potent, selective antagonists. Several analogues displayed oral bioavailability in vivo in the rat.
Pharmacophoric overlap of a high throughput screening hit and published OT antagonists followed by subsequent optimization led to a series of potent, selective Oxytocin antagonists (X). Several of these analogues showed oral bioavailability in vivo.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 15, 1 August 2008, Pages 4278–4281
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 15, 1 August 2008, Pages 4278–4281
نویسندگان
Alan Brown, Lindsay Brown, Dave Ellis, Nicholas Puhalo, Chris R. Smith, Olga Wallace, Lesa Watson,