کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1376378 981957 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design and optimization of potent, selective antagonists of Oxytocin
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design and optimization of potent, selective antagonists of Oxytocin
چکیده انگلیسی

A novel series of Oxytocin antagonists are described. This series was identified through pharmacophoric overlap of in-house and literature antagonists. Subsequent optimization led to a series of potent, selective antagonists. Several analogues displayed oral bioavailability in vivo in the rat.

Pharmacophoric overlap of a high throughput screening hit and published OT antagonists followed by subsequent optimization led to a series of potent, selective Oxytocin antagonists (X). Several of these analogues showed oral bioavailability in vivo.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 18, Issue 15, 1 August 2008, Pages 4278–4281
نویسندگان
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