کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1376484 | 981959 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor](/preview/png/1376484.png)
چکیده انگلیسی
Three deoxyglucose (DG) derivatives, S-DG, MAG3-DG and MAMA-BA-DG, were synthesized and labeled successfully with high labeling yields and high radio-chemical purities. Biodistribution in tumor-bearing mice demonstrated that these three new 99mTc-deoxyglucose derivatives showed accumulation in tumor and high tumor-to-muscle ratios. Among them, the 99mTc-MAG3-DG showed the best characteristics as a potential tumor marker for single photon emission computed tomography (SPECT).
The synthesis and evaluation of three 99mTc-labeled-deoxyglucose derivatives, 99mTc-S-DG, 99mTc-MAG3-DG, and 99mTc-MAMA-BA-DG were reported here.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5503–5506
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 21, 1 November 2006, Pages 5503–5506
نویسندگان
Xiangji Chen, Liang Li, Fei Liu, Boli Liu,