N,N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

A series of N-(2-hydroxy-3-sulfonamidobenzene)-N′-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to >200-fold.

A series of N-(2-hydroxy-3-sulfonamidobenzene)-N′-arylcyanoguanidines was prepared. In general, these compounds proved to be potent antagonists of CXCR2 while the selectivity versus CXCR1 ranged from non-selective to >200-fold.Figure optionsDownload as PowerPoint slide